Ezetimibe belongs to BCS class II drug and selectively inhibits the selection of cholesterol and related phytosterols. The tablets of ezetimibe are prepared by direct compression with different disintegrants and lubricates. Influence of disintegrants and lubricants on dissolution rate of the drug was studied. Various physical parameters like weight variation, friability, hardness, drug content, disintegration time, wetting time were also studied and dissolution parameters such as dissolution rate constant, and dissolution efficiency were calculated from the dissolution data. Most of the tablets complied with the pharmacopeial standards. In vitro dissolution studies were carried out in 500ml of 0.45% SLS in 0.05M acetate buffer as dissolution medium. Among all the super disintegrants, sodium starch glycolate showed a greater release and the tablets formulated with the lubricant PEG4000 showed a higher release compared to the tablets formulated with other lubricants.
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